Enantioselective 1, 6??Conjugate Addition of Dialkylzinc Reagents to Acyclic Dienones Catalyzed by Cu??DiPPAM Complex—Extension to Asymmetric Sequential 1, 6/ …

…, MST Morin, J Wencel??Delord…

Index: Wencel-Delord, Joanna; Alexakis, Alexandre; Crevisy, Christophe; Mauduit, Marc Organic Letters, 2010 , vol. 12, # 19 p. 4335 - 4337

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Citation Number: 13

Abstract

Transition-metal-catalyzed asymmetric conjugate addition (ACA) to electron-deficient unsaturated systems is an important method for the formation of CÀC bonds, among which the 1, 6-addition subtype is especially challenging, as a complete regiocontrol is more difficult to attain due to the presence of a supplementary reactive site.[1] Since first reports by Hayashi of Rh–diphosphine-catalyzed enantioselective 1, 6-additions of aryltitanates and ...