Tetrahedron letters

Solid-phase synthesis of 2, 6-and 2, 7-diamino-4 (3H)-quinazolinones via palladium-catalyzed amination

C Wéber, Á Demeter, GI Szendrei, I Greiner

Index: Weber, Csaba; Demeter, Adam; Szendrei, Gyoergyi I.; Greiner, Istvan Tetrahedron Letters, 2003 , vol. 44, # 40 p. 7533 - 7536

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Citation Number: 19

Abstract

A new procedure for the solid-phase synthesis of 2, 6-and 2, 7-diamino-4 (3H)- quinazolinones is described. The method involves coupling of 2, 4, 6-and 2, 4, 7- trichloroquinazoline to a solid support via benzyl alcohol type linkers, subsequent displacement of chlorine at C-2 then at the C-6 or C-7 positions by amines (Fig. 1) and the cleavage of the products from the resin. The palladium-catalyzed amination of C-6 and C- ...