I I1 well-known compounds as sulfonal, trional and tetronal. These compounds are rather toxic and cannot be used in certain cases of impairment of cardiac or renal function. They also have a very limited solubility in water, tetronal, the most active hypnotic, being only very slightly soluble. Many different alkyl groups have been inserted'in an effort to improve the pharmacological action. The effect of introducing other functional groups into the alkyl ...