e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis of. omega.-bromo ketones

HO House, CY Chu, WV Phillips…

Index: House,H.O. et al. Journal of Organic Chemistry, 1977 , vol. 42, # 10 p. 1709 - 1717

Full Text: HTML

Citation Number: 25

Abstract

Various methyl ketones 8, 9, 21, 24, 26, 27, 34, and 54 containing terminal vinyl groups have been synthesized by regiospecific alkylations of metal enolates with allyl bromide, by the conjugate addition of (CHz= CH) &uLi or CHz= CHMgBr with MelSCuBr as a catalyst to enones, and by other procedures. The light-catalyzed radical-chain addition of HBr in pentane solution to these olefinic ketones constituted an efficient method for the synthesis ...

Benzyl chloromethyl ether Structure

Benzyl chlorome...

3-methylbut-2-en-2-yl acetate Structure

3-methylbut-2-e...

~%

3,3-dimethyl-4-phenylmethoxybutan-2-one Structure

3,3-dimethyl-4-...

3-methylbut-2-en-2-yl acetate Structure

3-methylbut-2-e...

~%

3,3-dimethyl-2-hexanone Structure

3,3-dimethyl-2-...

3-methylbut-2-en-2-yl acetate Structure

3-methylbut-2-e...

~%

4-bromo-3,3-dimethylbutan-2-one Structure

4-bromo-3,3-dim...

3,3-dimethyl-4-phenylmethoxybutan-2-one Structure

3,3-dimethyl-4-...

~%

4-bromo-3,3-dimethylbutan-2-one Structure

4-bromo-3,3-dim...

N/A Structure

~%

1-(2,4-dimethylcyclobutyl)ethanone Structure

1-(2,4-dimethyl...

3-Penten-2-one Structure

~%

1-(2,4-dimethylcyclobutyl)ethanone Structure

1-(2,4-dimethyl...

3-methylbut-2-en-2-yl acetate Structure

3-methylbut-2-e...

~%

6-bromo-3,3-dimethylhexan-2-one Structure

6-bromo-3,3-dim...

3-Penten-2-one Structure

~%

4-methylhept-6-en-2-one Structure

4-methylhept-6-...

4,4-dimethylhex-5-en-2-one Structure

4,4-dimethylhex...

~%

6-bromo-4,4-dimethylhexan-2-one Structure

6-bromo-4,4-dim...

Mesityl oxide Structure

~%

6-bromo-4,4-dimethylhexan-2-one Structure

6-bromo-4,4-dim...

4-methylhept-6-en-2-one Structure

4-methylhept-6-...

~%

7-bromo-4-methylheptan-2-one Structure

7-bromo-4-methy...

3-Penten-2-one Structure

~%

7-bromo-4-methylheptan-2-one Structure

7-bromo-4-methy...

N/A Structure

~%

7-bromo-4-methylheptan-2-one Structure

7-bromo-4-methy...

3-Penten-2-one Structure

Vinylmagnesium bromide Structure

Vinylmagnesium ...

~%

5-Hexen-2-one, 4-methyl- (7CI,9CI) Structure

5-Hexen-2-one, ...

Mesityl oxide Structure

Vinylmagnesium bromide Structure

Vinylmagnesium ...

~%

4,4-dimethylhex-5-en-2-one Structure

4,4-dimethylhex...