Acta Poloniae Plìarmaceutica-Drug Research

SYNTHESIS AND ANTICONVULSANT PROPERTIES OF A SERIES OF/V-SUBSTITUTED 2-AZA-SPIRO [4.5] DECANE-l, 3-DIONES AND 8-PHENYL-2-AZA- …

J OBNISKA

Index: Obniska, Jolanta Acta Poloniae Pharmaceutica - Drug Research, 2004 , vol. 61, # 6 p. 467 - 472

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Citation Number: 8

Abstract

Abstract: A series of/V-phenyl-2-aza-spiro [4.5] decane-l, 3-diones [III-VIII], structurally related to the previously described/V-phenyl-3-aryIpyrrolidine-2, 5-dione (li), was synthesized and tested for their anticonvulsant activity in the maximum electroshock seizure (MES) and metrazole seizure threshold (sc. MET) tests. The most potent of the series were V- (2-methylphenyl)-2-aza-spiro [4.5] decane-l, 3-dione [III| and ЛЧЗ-тетуфпепу!)-2-aza-spiro ...