Synthesis and antiviral activity of organic and organophosphorus derivatives of α-aminonitriles

…, LK Nikonorova, GK Gil'manova, OK Pozdeev

Index: Gubanova, G. S.; Zhelonkina, L. A.; Zapaska, I. A.; Nikonorova, L. K.; Gil'manova, G. Kh.; Pozdeev, O. K. Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 7 p. 619 - 622 Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 7-8 p. 60 - 62

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Abstract

N-Alkyl-N-cyanomethyl (chloro, dichloro~:~ richloro) acet (benz) amides (I)-(VIII), A mix~ ture of the nitrile of the alkylaminoacetic acid (0.133 mole) and triethylamine (0.136 mole) in benzene (50 ml) was added dropwise with stirring and cooling (5~ to 0.133 mole of chloro-, dichloro-, or trichloroacetyl chloride in dry benzene (60 ml). The triethylamine was filtered from the reaction mixture on the following day, the benzene distilled off, and the residue ...