Chemistry of heterocyclic compounds. 23. Synthesis of multiheteromacrocycles possessing 2, 6-pyridino subunits connected by carbon-oxygen linkages

GR Newkome, A Nayak, GL McClure…

Index: Newkome,G.R. et al. Journal of Organic Chemistry, 1977 , vol. 42, p. 1500 - 1508

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Citation Number: 32

Abstract

17a. R= H b: R= Ac subjected to the Dieckmann condensation in order to form oxometacyclophanes, the inability to generate a ten-membered ring and reluctance in the formation of the 12-membered cyclophane were indicative of the nonbonded interactions which either retard or reduce the desired nucleophilic cycli~ ation.~ It should be noted that 2, 6-[n] pyridinophanes, where n is less than 10, can be synthesized if (a) 2, 6-dihalopyridine ...