Efficient approach to acyloxymethyl esters of nalidixic acid and in vitro evaluation as intra-ocular prodrugs

J Azéma, B Guidetti, M Malet-Martino, R Martino…

Index: Azema, Joelle; Guidetti, Brigitte; Malet-Martino, Myriam; Martino, Robert; Roques, Christine Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 8 p. 2569 - 2580

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Citation Number: 11

Abstract

Various alkylcarbonyloxymethyl esters of nalidixic acid ranging from 3 to 15 carbon units in the pro-moiety have been prepared and assessed as potential prodrugs. Their chromatographic retention factors k′, silicone oil solubilities and in vitro conversion to ...