Abstract The synthesis of glucuronides derived from mianserin and its 6-aza analogue (Org 3770) is described. Several methods were investigated. The most successful approach was the coupling of 1, 2, 3, 4, 10, 14b-hexahydro-8-hydroxy-2-(trifluoroacetyl) dibenzo [c, f] pyrazino [1, 2-a] azepine or its 6-aza analogue with methyl [trichloroethanimidoyl 2, 3, 4-tris- O-(phenylmethyl)-α-D-glucopyranosid] uronate catalyzed by BF 3. Fully protected ...
