Synthesis and antibacterial screening of hydrazones, Schiff and Mannich bases of isatin derivatives

SK Sridhar, M Saravanan, A Ramesh

Index: Sridhar, Seshaiah Krishnan; Saravanan, Muniyandy; Ramesh, Atmakuru European Journal of Medicinal Chemistry, 2001 , vol. 36, # 7-8 p. 615 - 625

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Citation Number: 332

Abstract

Schiff bases and hydrazones of substituted isatins (1–28) were prepared by reacting isatin and aromatic primary amines/hydrazines. A new series of the corresponding N-Mannich base (29–35) was synthesised by reacting them with formaldehyde and diphenyl amine. The chemical structures were confirmed by means of 1H-NMR, IR spectral data and elemental analysis. The compounds were screened for antibacterial activity against seven Gram (+) ...