Synthesis of L??Propargylglycine and Derivatives

O Leukart, M Caviezel, A Eberle, E Escher…

Index: Leukart,O. et al. Helvetica Chimica Acta, 1976 , vol. 59, p. 2181 - 2183

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Citation Number: 26

Abstract

Ac-NH- Ce Nae + Br-CH2-CECH --+ Ac-NH-C-CHa-CECH -+ Ac-NH-C-CH2-C=CH I COOEt 1 2 ... I I @ I I H I H I H 3 (D, L) 4 (D, L) 5 (L-Pra) ... ----+ Ac-NH-C-CH~-CECH --+ Ac-NH-C-CH2 -C-CH --+ H3N-C-CH2-C=CH ... Scheme 2 5 --+ PHT=Pra. OH. DCHA --+ PHT=Pra. OMe 6 (4 7 (L) 3 --+ HC1, H . Pra . OH --+ BOC Pra * OH. DCHA --+ BOC * Pra OTSE 8 (D, L) 9 (D, L) 10 (D, L) ... PHT=Pra 1 OBut 11 (D, L) 1) This work was supported by the ...