Discovery of hepatitis C virus NS3-4A protease inhibitors with improved barrier to resistance and favorable liver distribution

…, JA O'Meara, J Bordeleau, M Garneau…

Index: Moreau, Benoiit; O'Meara, Jeff A.; Bordeleau, Josee; Garneau, Michel; Godbout, Cedrickx; Gorys, Vida; Leblanc, Melissa; Villemure, Elisia; White, Peter W.; Llinas-Brunet, Montse Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1770 - 1776

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Citation Number: 14

Abstract

Given the emergence of resistance observed for the current clinical-stage hepatitis C virus (HCV) NS3 protease inhibitors, there is a need for new inhibitors with a higher barrier to resistance. We recently reported our rational approach to the discovery of macrocyclic ...