Synthesis, crystal structure and evaluation of cancer inhibitory activity of 4-[indol-3-yl-methylene]-1H-pyrazol-5 (4H)-one derivatives

L Jing, L Wang, Y Zhao, R Tan, X Xing…

Index: Jing, Lingling; Wang, Liang; Zhao, Yinglan; Tan, Rui; Xing, Xiumei; Liu, Ting; Huang, Wencai; Luo, Youfu; Li, Zicheng Journal of Chemical Research, 2012 , vol. 36, # 12 p. 691 - 696

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Abstract

A series of 4-(1H-indol-3-yl-methylene)-1H-pyrazol-5 (4H)-one derivatives have been synthesised. The Z structure of 4-[(1-methyl-1H-indol-3-yl) methylene]-3-phenyl-1-p-tolyl-1H- pyrazol-5-one was determined by X-ray crystallography. The antitumour activity was evaluated against five cancer cells by MTT assay.[(1H-Indol-3-yl) methylene]-1-(2, 4- dinitrophenyl)-3-methyl-1H-pyrazole-5-one and 4-{4-[(1-benzyl-1H-indol-3-yl) methylene]- ...