. gamma.-Alkylation of. alpha.,. beta.-unsaturated ketones.. gamma.-Arylsulfonyl groups as regioselective control elements

PT Lansbury, RW Erwin, DA Jeffrey

Index: Lansbury, Peter T.; Erwin, Robert W.; Jeffrey David A. Journal of the American Chemical Society, 1980 , vol. 102, # 5 p. 1602 - 1608

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Citation Number: 29

Abstract

Abstract: A reaction sequence for y-alkylation of cu, P-unsaturated ketones has been proposed and tested with some success. y-(Phenylsulfonyl) groups are (I) introduced into the substrate;(2) present during alkylation of the resulting highly delocalized carbanions;(3) finally removed to leave the otherwise inaccessible y-alkylation product.