Open-chain nitrogen compounds. Part XII. Methanolysis of 3-alkyl-3, 4-dihydro-1, 2, 3-benzotriazin-4-ols: evidence for ring-chain tautomerism with the cytotoxic …

RJ Lafrance, HW Manning…

Index: LaFrance, Ronald; Manning, Hartford W.; Vaughan, Keith Canadian Journal of Chemistry, 1987 , vol. 65, p. 292 - 297

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Citation Number: 6

Abstract

A series of 4-hydroxy-3, 4-dihydro-1, 2, 3-benzotriazines (" triazinols"), potential pro-drugs for the cytotoxic monoalkyltriazenes, have been investigated for anti-tumor activity and have been found to have marginal activity against the TLX5 tumor. The in vivo anti-tumor activity correlates with previously observed in vitro cytotoxicity of the compounds. The chemical behaviour of the triazinols is consistent with carbinolamine triazene ring-chain ...