Bulletin of the Chemical Society of Japan

A synthesis of optically active 4-diethoxyphosphinyl-3-(1-hydroxyethyl)-2-azetidinone: A potential precursor to (1-aminoalkyl)-phosphonic acid derivatives.

M Shiozaki, H Masuko

Index: Shiozaki, Masao; Masuko, Hidekazu Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 2 p. 645 - 648

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Citation Number: 12

Abstract

Optically active 4-diethoxyphosphinyl-3-(1-hydroxyethyl)-2-azetidinone (8) was synthesized from (2R, 3R) N-diethoxyphosphinylmethyl-2, 3-epoxybutyramide derivatives, and compound 8 was alternatively synthesized from (3R, 4R)-4-acetoxy-3-[(R)-1-(t- butyldimethylsilyloxy) ethyl]-2-azetidinone via 3-[1-(t-butyldimethylsilyloxy) ethyl] derivative.