Organic letters

Chemoenzymatic approaches to lycorine-type amaryllidaceae alkaloids: total syntheses of ent-lycoricidine, 3-epi-ent-lycoricidine, and 4-deoxy-3-epi-ent-lycoricidine

M Matveenko, OJ Kokas, MG Banwell, AC Willis

Index: Matveenko, Maria; Kokas, Okanya J.; Banwell, Martin G.; Willis, Anthony C. Organic Letters, 2007 , vol. 9, # 18 p. 3683 - 3685

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Citation Number: 52

Abstract

The readily available and enzymatically derived cis-1, 2-dihydrocatechol 4 has been elaborated, over 11 steps including an Overman rearrangement, into the non-natural enantiomer,(-)-1, of the alkaloid lycoricidine [(+)-1]. Related chemistries have provided analogues 18, 19, and 26.