Synthesis of 2, 4-disubstituted thiazoles and selenazoles as potential antifilarial and antitumor agents. 2. 2-Arylamido and 2-alkylamido derivatives of 2-amino-4-( …

Y Kumar, R Green, DS Wise, LL Wotring…

Index: Kumar, Yatendra; Green, Rachel; Wise, Dean S.; Wotring, Linda L.; Townsend, Leroy B. Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3849 - 3852

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Citation Number: 86

Abstract

The synthesis of a series of 2-arylamido and 2-alkylamido derivatives of 2-amino-4- (isothiocyanatomethy1) thiazole and 2-amino-4-(isothiocyanato~ ethyl) selenazole is described. In vitro antiproliferative evaluations were carried out using L1210 cells. The 2- (alky1amido) thiazole derivatives were moderately antiproliferative, with ICm's of 4-8 pM. A aignificant increase in activity was obtained for the arylamido derivatives, with 1C~'s of 0.2 ...