Tetrahedron

Reactivity of β-amino alcohols against dialkyl oxalate: synthesis and mechanism study in the formation of substituted oxalamide and/or morpholine-2, 3-dione …

ML Testa, E Zaballos, RJ Zaragozá

Index: Testa, Maria Luisa; Zaballos, Elena; Zaragoza, Ramon J. Tetrahedron, 2012 , vol. 68, # 47 p. 9583 - 9591,9

Full Text: HTML

Citation Number: 7

Abstract

The reactivity of various β-amino alcohols with dialkyl oxalates, in several reaction conditions, has been investigated. Linear disubstituted oxalamides were obtained with primary β-amino alcohols and linear tetrasubstituted oxalamides, or a mixture of linear tetrasubstituted oxalamides and cyclic morpholine-2, 3-diones were obtained with N- substituted β-amino alcohols. A DFT study of the possible mechanism has been made. ...