Journal of the American Chemical Society

7-Deoxydaunomycinone, a catalyst for achieving a two electron reduction with a one electron reducing agent

DL Kleyer, TH Koch

Index: Kleyer, Don L.; Koch, Tad H. Journal of the American Chemical Society, 1983 , vol. 105, # 18 p. 5911 - 5912

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Citation Number: 17

Abstract

7-Deoxydaunomycinone (1) is the product of reductive elimination of daunosamine from the antileukemic drug daunomycin (2).* The reductive cleavage process leads to reactive intermediate~~ that are proposed to combine with DNA to give 1 covalently bound to DNA. 4, 5 Subsequent chemistry of bound 1 as a redox catalyst likely leads to cell death. 6 Previously we demonstrated that the reducing agent dl-bi-(3, 5, 5-trimethyl-2- ...