Synthesis of 1, 4, 7, 8, 9, 10-hexahydro-9-methyl-6-nitropyrido [3, 4-f]-quinoxaline-2, 3-dione and related quinoxalinediones: characterization of. alpha.-amino-3- …

…, CB Nelson, DF Ortwine, R Schelkun…

Index: Bigge; Malone; Boxer; Nelson; Ortwine; Schelkun; Retz; Lescosky; Borosky; Vartanian; Schwarz; Campbell; Robichaud; Watjen Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3720 - 3740

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Citation Number: 64

Abstract

Four related series of substituted quinoxalinediones containing angular fused-piperidine rings have been synthesized as a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists with potential as neuroprotective agents, primarily for acute therapy immediately following a stroke. 2 The compounds were tested for their affinity to the AMPA, kainate, and strychnine-insensitive glycine receptor sites. In AMPA binding, the ...