Tetrahedron

Stereochemical studies of 2-hydroxychromanones by 1H NMR spectroscopy

J Borbély, V Szabó, PL Sohár

Index: Borbely, Janos; Szabo, Vince; Sohar, Pal Tetrahedron, 1981 , vol. 37, p. 2307 - 2312

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Citation Number: 10

Abstract

2-Hydroxychromanones (2a–2f) were synthesized by ring closing of 2- hydroxyacetophenones (1a, b) and 2-hyroxypropiophenones (1c–1f). In the case of 2- hydroxy-3-methyl-chromanones (2c–2f) a mixture of cis and trans isomers was obtained. The trans isomers are conformalionally homogeneous, the cis isomers exist in a conformational equilibrium. At room temperature the isomers are transformed into each ...