Chemistry–A European Journal

Application of the Intramolecular Isomerisation–Aldolisation from Allylic Alcohols and Allylic Silyl Ethers to the Synthesis of Indanones and Indenones

J Petrignet, T Roisnel, R Gree

Index: Petrignet, Julien; Roisnel, Thierry; Gree, Rene Chemistry - A European Journal, 2007 , vol. 13, # 26 p. 7374 - 7384

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Citation Number: 40

Abstract

Abstract A new access to indanones was discovered through a one-step nickel or iron- mediated transposition of 2-hydroxyisobenzofurans. Starting from the corresponding silylenol ethers, a new one-pot tandem isomerisation–Mukaiyama aldol process was also developed. These versatile strategies will be useful for the preparation of various types of indanones and indenones.