Synthesis of Spiro-β-Methylene-γ-Butyrolactones

TJ Brocksom, MG Constantino…

Index: Brocksom,T.J. et al. Synthetic Communications, 1977 , vol. 7, p. 483 - 493

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Citation Number: 7

Abstract

Abstract The Bakkenolide group 1 3 of sesquiterpenes present two interesting synthetic problems. The cisdimethyl cis-hydrindane portion 2, because of its structural and stereochemical relationship with the eremophilane sesqui terpenes, 4 has synthetic solutions available. 5 The spiro-β-methylene-γ-butyrolactone unit 3, 6 which is presently unique to this class of natural products, has been synthesised by four different routes. 7–10