A systematic investigation of quaternary ammonium ions as asymmetric phase-transfer catalysts. Synthesis of catalyst libraries and evaluation of catalyst activity

SE Denmark, ND Gould, LM Wolf

Index: Denmark, Scott E.; Gould, Nathan D.; Wolf, Larry M. Journal of Organic Chemistry, 2011 , vol. 76, # 11 p. 4260 - 4336

Full Text: HTML

Citation Number: 60

Abstract

Despite over three decades of research into asymmetric phase-transfer catalysis (APTC), a fundamental understanding of the factors that affect the rate and stereoselectivity of this important process are still obscure. This paper describes the initial stages of a long-term program aimed at elucidating the physical organic foundations of APTC employing a chemoinformatic analysis of the alkylation of a protected glycine imine with libraries of ...