N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[131I] iodo-5-methoxybenzyl) acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain

…, J Noguchi, T Suhara, C Halldin, K Suzuki

Index: Zhang, Ming-Rong; Kumata, Katsushi; Maeda, Jun; Haradahira, Terushi; Noguchi, Junko; Suhara, Tetsuya; Halldin, Christer; Suzuki, Kazutoshi Journal of Medicinal Chemistry, 2007 , vol. 50, # 4 p. 848 - 855

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Citation Number: 24

Abstract

To image the peripheral-type benzodiazepine receptor (PBR) in vivo, we previously developed two positron emission tomography (PET) ligands, N-(2-[11C], 5-dimethoxybenzyl)- N-(5-fluoro-2-phenoxyphenyl) acetamide ([11C] 1a) and its [18F] fluoroethyl analogue ([18F] 1b), for the investigation of PBR in the living human brain. This time, using 1a as a leading compound, we designed two novel iodinated analogues, N-(5-fluoro-2-phenoxyphenyl)-N ...