Synthesis of novel histamine H4 receptor antagonists

…, D Hay, CE Mowbray, M Paradowski, MD Selby…

Index: Lane, Charlotte A.L.; Hay, Duncan; Mowbray, Charles E.; Paradowski, Michael; Selby, Matthew D.; Swain, Nigel A.; Williams, David H. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1156 - 1159

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Citation Number: 17

Abstract

This letter describes the discovery and synthesis of a series of octahydropyrrolo [3, 4-c] pyrrole based selective histamine hH4 receptor antagonists. The amidine compound 20 was found to be a potent and selective histamine H4 receptor antagonist with moderate clearance and a high volume of distribution.