Metal??Free Synthesis of Sterically Crowded Biphenyls by Direct Ar H Substitution in Alkyl Benzenes

V Dichiarante, M Fagnoni…

Index: Dichiarante, Valentina; Fagnoni, Maurizio; Albini, Angelo Angewandte Chemie - International Edition, 2007 , vol. 46, # 34 p. 6495 - 6498

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Citation Number: 47

Abstract

A biaryl moiety is a common structural component of many pharmaceutically and biologically active compounds.[1] Therefore, the synthesis of asymmetric or crowded biaryl compounds is a significant challenge. In recent decades, traditional methods, such as the Ullmann and Gomberg reactions, have been supplanted by novel transition-metal-catalyzed processes.[2] These reactions involve the coupling of a nucleophilic organometallic derivative ArÀM (M= ...