Synthesis of 2??(1??Phenylvinyl) benzofurans and 2??(1??Phenylvinyl) indoles as Antimitotic Agents by a Tandem Palladium??Assisted Coupling??Cyclization Reaction …

…, J Wdzieczak??Bakala, J Dubois…

Index: Treguier, Bret; Rasolofonjatovo, Evelia; Hamze, Abdallah; Provot, Olivier; Wdzieczak-Bakala, Joanna; Dubois, Joelle; Brion, Jean-Daniel; Alami, Mouad European Journal of Organic Chemistry, 2011 , # 25 p. 4868 - 4876

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Citation Number: 3

Abstract

Abstract A series of functionalized 2-(1-phenylvinyl) benzofurans 2 and 2-(1-phenylvinyl) indoles 3 were prepared from 1-phenylvinyl iodides and silylated alkynes in a one-pot reaction. After a desilylation step, the Sonogashira coupling reaction between the resulting terminal alkynes and 1-phenylvinyliodide derivatives 6 gave enyne intermediates, which underwent a 5-endo-dig cyclization to afford 2-(1-phenylvinyl) heterocycles 2 and 3 in ...