In attempt to make significant pharmacologically active molecule, we report here the synthesis and in vitro antimicrobial and antitubercular activity of various series of 3-(3- pyridyl)-5-(4-nitrophenyl)-4-(N-substituted-1, 3-benzothiazol-2-amino)-4 H-1, 2, 4-triazole. The antimicrobial activity of title compounds were examined against two Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), two Gram-negative bacteria ( ...