Diamine derivatives containing imidazolidinylidene propanedinitrile as a new class of histamine H 3 receptor antagonists. Part I

…, M Kawamura, R Hirose, S Toki, J Shimada

Index: Sasho, Setsuya; Seishi, Takashi; Kawamura, Mariko; Hirose, Ryo; Toki, Shinichiro; Shimada, Jun-ich Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 7 p. 2288 - 2291

Full Text: HTML

Citation Number: 7

Abstract

Novel diamine derivatives containing imidazolidinylidene propanedinitrile were synthesized and evaluated for histamine H3 receptor-binding affinities. High-affinity ligands 3d, 3k, and 3n showed potent H3 receptor antagonism and excellent selectivity over human H1, H2 and H4 receptors.