Synthesis, spectroscopic characterization, antineoplastic, in vitro-cytotoxic, and antibacterial activities of mononuclear ruthenium (II) complexes

…, M Imran, M Udugula, SS Karki, N Kanjarla…

Index: Thota, Sreekanth; Imran, Mohammad; Udugula, Manasa; Karki, Subhas Somalingappa; Kanjarla, Narasimha; Yerra, Rajeshwar; Balzarini, Jan; De Clercq, Erik Journal of Coordination Chemistry, 2012 , vol. 65, # 5 p. 823 - 839

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Citation Number: 16

Abstract

The synthesis, antineoplastic, cytotoxic, and antibacterial activities of Ru (II) complexes derived from quinazoline and thiosemicarbazone ligands are reported. These complexes have been prepared and characterized by UV-Vis, IR, 1H-NMR, FAB-mass spectroscopy, and elemental analysis. The ligands and resulting complexes were subjected to in vivo antineoplastic activity against a transplantable murine tumor cell line Ehrlich ascites ...