Organic & biomolecular chemistry

Benzofuran and indole synthesis via Cu (I)-catalyzed coupling of N-tosylhydrazone and o-hydroxy or o-amino phenylacetylene

T Xiao, X Dong, L Zhou

Index: Xiao, Tiebo; Dong, Xichang; Zhou, Lei Organic and Biomolecular Chemistry, 2013 , vol. 11, # 9 p. 1490 - 1497

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Citation Number: 21

Abstract

A general and practical method to synthesize 2-substituted benzofurans and indoles is described. This method employs easily accessible N-tosylhydrazones and o-hydroxy or o- amino phenylacetylenes as substrates. The reaction proceeds through a CuBr-catalyzed coupling–allenylation–cyclization sequence under ligand-free conditions.