Acidic triazoles as soluble guanylate cyclase stimulators

…, SE Heasley, J Molette, GL Smith, MA Schmidt…

Index: Roberts, R. Lee; Bradley, A. Paul; Bunnage, E. Mark; England, S. Katherine; Fobian, M. Yvette; Fox, N.A. David; Gymer, Geoff E.; Heasley, Steven E.; Molette, Jerome; Smith, Graham L.; Fairman, David; Schmidt, Michelle A.; Tones, Michael A.; Dack, Kevin N. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6515 - 6518

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Citation Number: 18

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF 3 triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25. ... A series of acidic triazoles with activity as soluble ...