Tetrahedron Letters

Efficient synthesis of prasugrel, a novel P2Y 12 receptor inhibitor

X Pan, R Huang, J Zhang, L Ding, W Li, Q Zhang…

Index: Pan, Xianhua; Huang, Rui; Zhang, Jianshui; Ding, Liping; Li, Weijin; Zhang, Qunhui; Liu, Feng Tetrahedron Letters, 2012 , vol. 53, # 40 p. 5364 - 5366

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Citation Number: 11

Abstract

An efficient synthesis of prasugrel, a novel P2Y12 receptor inhibitor, is described. The cyclopropyl-phenylethanone intermediate was prepared by cyanide substitution, bromination, N-substitution, and the Grignard reaction. After acid hydrolyzation of the methyl ether and subsequent acetylation, the title product was obtained with a total yield of 21% after 10 linear steps from simple and commercially available raw materials.