A topliss tree analysis of the HIV-protease inhibitory activity of 6-phenyl-4-hydroxy-pyran-2-ones

…, KS Para, PJ Tummino, D Ferguson, EA Lunney…

Index: Steinbaugh; Hamilton; Prasad; Para; Tummino; Ferguson; Lunney; Blankley Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 10 p. 1099 - 1104

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Citation Number: 12

Abstract

In a study of 4-hydroxy-pyran-2-ones as possible inhibitors of HIV protease, a series of compounds were synthesized following the Topliss operational scheme for substitution on a phenyl group at the 6 position of the pyrone. In addition, a number of compounds with polar substituents were made.