e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
A detailed investigation of the aza-Prins reaction
…, RJ Parker, J Skidmore, RA Stephenson…
Index: Dobbs, Adrian P.; Guesne, Sebastien J. J.; Parker, Robert J.; Skidmore, John; Stephenson, Richard A.; Hursthouse, Mike B. Organic and Biomolecular Chemistry, 2010 , vol. 8, # 5 p. 1064 - 1080
The development of a Lewis acid-promoted aza-Prins reaction to form piperidines and pyrrolidines is described. Indium trichloride has been found to be a highly successful and mild Lewis acid for promoting this reaction. A thorough mechanistic investigation is described, including the factors that influence the formation of the 5-or 6-membered ring product (s).
[Ewing, James C.; Ferguson, Gregory S.; Moore, Douglas W.; Schultz, Frederick W.; Thompson, David W. Journal of Organic Chemistry, 1985 , vol. 50, # 12 p. 2124 - 2128]
