Iron??Catalyzed Synthesis of β??Chlorovinyl and α, β??Alkynyl Ketones from Terminal and Silylated Alkynes with Acid Chlorides

P Gandeepan, K Parthasarathy, TH Su…

Index: Gandeepan, Parthasarathy; Parthasarathy, Kanniyappan; Su, Tsu-Hui; Cheng, Chien-Hong Advanced Synthesis and Catalysis, 2012 , vol. 354, # 2-3 p. 457 - 468

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Citation Number: 19

Abstract

Abstract A simple efficient method for the iron (III)-catalyzed synthesis of substituted β- chlorovinyl ketones and α, β-alkynyl ketones from terminal and silyl-substituted alkynes with acid chlorides, respectively, is described. This method features easily available starting materials, a cheap and non-toxic catalyst, simple manipulation and mild reaction conditions. Evidence shows that the catalytic addition of the acid chloride to a terminal alkyne to give ( ...