Hypolipidemic arylthioalkanoic acids

ER Wagner, RG Dull, LG Mueller, BJ Allen…

Index: Wagner,E.R. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 1007 - 1013

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Citation Number: 12

Abstract

A series of arylthioalkanoic acids related to probucol was studied for hypolipidemic activity. Homologation of the alkyl side chain led to marked changes in the serum cholesterol and serum triglyceride lowering activity in rats with the best combination of properties appearing in compound 7, 2-[(3, 5-di-tert-butyl-4-hydroxyphenyl) thio] hexanoic acid. Modification of the ring substitution failed to improve the activity despite the empirical observation that ...