Synthetic Communications

Convenient method for the preparation of the 2-methyl thiophen-3-yl magnesium bromide lithium chloride complex and its application to the synthesis of 3-substituted …

M Kogami, N Watanabe

Index: Kogami, Masakazu; Watanabe, Nobuhide Synthetic Communications, 2013 , vol. 43, # 5 p. 681 - 688

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Citation Number: 2

Abstract

Lithium chloride was found to accelerate formation of the Grignard reagent from inactive 3-bromo-2-methylthiophene (1) and commercial magnesium metal. Based on this finding, a convenient and potentially scalable preparation of ethyl 2-methylthiophene-3-carboxylate (3) was achieved. In addition, this process has been found to provide a new, general approach to 3-substituted 2-methylthiophenes. ... Lithium chloride was found to accelerate formation of the ...