Abstract The enantioselective total synthesis of the biologically active 1, 4-benzodioxane lignans isoamericanin A (2) and isoamericanol A (3) has been achieved in 11 and 12 steps, respectively. These benzodioxane lignan natural products, and others that contain 9- hydroxymethyl group, show a wide range of biological properties. The 1, 4-benzodioxane ring was formed by an acid-catalysed cyclisation, which gave the desired trans isomer ...
[Chittimalla, Santhosh Kumar; Bandi, Chennakesavulu; Putturu, Sireesha; Kuppusamy, Rajesh; Boellaard, Kevin Christopher; Tan, David Chu Aan; Lum, Demi Ming Jie European Journal of Organic Chemistry, 2014 , vol. 2014, # 12 p. 2565 - 2575]
