Antifungal agents. 1. Synthesis and antifungal activities of estrogen-like imidazole and triazole derivatives

…, R Di Santo, A Retico, M Artico, N Simonetti…

Index: Massa; Di Santo; Retico; Artico; Simonetti; Fabrizi; Lamba European Journal of Medicinal Chemistry, 1992 , vol. 27, # 5 p. 495 - 502

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Citation Number: 45

Abstract

Abstract The synthesis of some 2-aryl-1-(4-methoxyphenyl)-1-(1H-imidazol-1-yl) ethane derivatives and related 1H-1, 2, 4-and 1H-1, 3, 4-triazoles is described. The molecular structure of new derivatives has been established by 1H NMR spectra and X-ray crystallographic analysis. When tested in solid agar cultures the azole derivatives showed from moderate to potent in vitro antifungal activity against Candida albicans and Candida ...