Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4 (3) H-ones

…, S Ganguly, R Veerasamy, E De Clercq

Index: Kumar, Krishnan Suresh; Ganguly, Swastika; Veerasamy, Ravichandran; De Clercq, Erik European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 5474 - 5479

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Citation Number: 74

Abstract

A new series of 3-(benzylideneamino)-2-phenylquinazoline-4 (3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4 (3) H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes ...