A new series of 3-(benzylideneamino)-2-phenylquinazoline-4 (3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4 (3) H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against herpes simplex virus-1 (KOS), herpes simplex virus-2 (G), vaccinia virus, vesicular stomatitis virus, herpes ...