Solid??Phase Synthesis Using (Allyloxy) carbonyl (Alloc) Chemistry of a Putative Heptapeptide Intermediate in Vancomycin Biosynthesis Containing m??Chloro??3?? …

…, F Vitali, A Linden, JA Robinson

Index: Freund, Ernst; Vitali, Francesca; Linden, Anthony; Robinson, John A. Helvetica Chimica Acta, 2000 , vol. 83, # 9 p. 2572 - 2579

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Citation Number: 8

Abstract

Abstract A convenient method for the solid-phase synthesis of putative linear heptapeptide intermediates in vancomycin biosynthesis is described, in particular, the heptapeptide D-Leu- Cyt-L-Asn-Hpg-Hpg-Cyt′-Dhpg (Cyt=(2R, 3R)-m-chloro-3-hydroxytyrosine, Hpg=(R)-2-(p- hydroxyphenyl) glycine, Cyt′=(2S, 3R)-m-chloro-3-hydroxytyrosine and Dhpg=(S)-2-(3, 5- dihydroxyphenyl) glycine). The synthesis was performed on chlorotrityl resin and ...