Synthesis of optically active. beta.-lactams by the photolytic reaction of imines with optically active chromium carbene complexes. 2. Synthesis of 1-carbacephalothin …

Y Narukawa, KN Juneau, D Snustad…

Index: Narukawa; Juneau; Snustad; Miller; Hegedus Journal of Organic Chemistry, 1992 , vol. 57, # 20 p. 5453 - 5462

Full Text: HTML

Citation Number: 43

Abstract

A relay (3) to optically active 1-carbacephalothin (4) was prepared in modest yield with high stereoselectivity by the photochemical reaction of optically active chromium carbene complex 1 with functionalized imine 2. In contrast, the photochemical reaction of carbene complex 1 with imine precursors 15a, b to the nocardicins was much less stereoselective.