Microbial decyanation of 1-benzylpyrrolidine-2, 5-dicarbonitrile. Mechanistic investigations

…, D Buisson, S Cortial, M Delaforge, J Ouazzani

Index: Pinheiro, Lucimar; Buisson, Didier; Cortial, Sylvie; Delaforge, Marcel; Ouazzani, Jamal Journal of Molecular Catalysis B: Enzymatic, 2011 , vol. 68, # 2 p. 211 - 215

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Citation Number: 2

Abstract

Various bacterial and fungal strains were screened for their ability to catalyse the regioselective hydrolysis of 1-benzylpyrrolidine-2, 5-dicarbonitrile (1). Among the examined strains, Rhodococcus opacus sp-lma whole cells transformed both isomers of 1 into 1- benzyl-5-cyano-2-pyrrolidinone (2) and N-benzylacetamide (3). These reactions are difficult to achieve chemically and the synthesis of compound 2 did not compete with ...