Development of a [3+ 3] cycloaddition strategy toward functionalized piperidines

SJ Hedley, WJ Moran, DA Price…

Index: Hedley, Simon J.; Moran, Wesley J.; Price, David A.; Harrity, Joseph P. A. Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4286 - 4292

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Citation Number: 74

Abstract

This paper describes a novel route to functionalized piperidines via a formal [3+ 3] cycloaddition reaction of activated aziridines and palladium-trimethylenemethane (Pd-TMM) complexes. The cycloaddition reaction generally proceeds enantiospecifically with ring opening at the least hindered site of the aziridine. Therefore, readily available enantiomerically pure 2-substituted aziridines can be utilized to prepare enantiomerically ...