e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis of 3 (5)-Amino-4-acylamino-5 (3)-arylsulfanylpyrazoles and Their Fused Derivatives on the Basis of N-(2, 2, 2-Trichloro-1-hydroxyethyl) benzamides
SV Popil'nichenko, SG Pil'o, BS Brovarets…
Index: Popil'nichenko; Pil'o; Brovarets; Chernega; Drach Russian Journal of General Chemistry, 2005 , vol. 75, # 11 p. 1816 - 1820
Abstract Addition products of carboxylic acid amides and trichloroacetaldehyde are readily converted into 3-arylsulfanyl-2-acylamino-3-chloroacrylonitriles which react with hydrazine hydrate to afford 3 (5)-amino-5 (3)-arylsulfanyl-4-acylaminopyrazoles. The presence of an amidine fragment in the latter makes them capable of undergoing cyclocondensations with β- dicarbonyl compounds and ethyl cyanoacetate.
