Arkivoc

Three component Kabachnik-Fields condensation leading to substituted aminomethane-P-hydroxymethylphosphonic acids as a tool for screening of bacterial …

S Vassiliou, A Grabowiecka, P Kosikowska, Ł Berlicki

Index: Vassiliou, Stamatia; Grabowiecka, Agnieszka; Kosikowska, Paulina; Berlicki, Lukasz Arkivoc, 2012 , vol. 2012, # 4 p. 33 - 43

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Citation Number: 8

Abstract

Abstract Condensation of hydroxyalkane-H-phosphinic acids, formaldehyde and secondary amines has given entry to the synthesis of variously substituted aminomethane-P- hydroxymethylphosphinic acids. The proposed strategy allowed to perform a feasible synthesis of several molecules with designed biological activity towards bacterial urease–an enzyme which is a medicinally relevant molecular target. The inhibitory potency of ...