Owing to the high nucleophilicity and the ready availability of organolithiums, coupling reactions of alkyl halides with organolithiums have been widely used for carbon–carbon bond formations in organic synthesis. 1, 1a, 1b, 1c, 1d, 1e, 1f and 1g The reaction of primary alkyl halides can proceed smoothly without any catalyst. However, the use of sterically bulky secondary alkyl halides as substrates in the coupling reactions often results in affording the corresponding ...
